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Lena-Alexandra Beume
Dr. med.
Lena-Alexandra Beume
Oberärztin

 

  • Geriatrie
  • Neurologie
  • Stroke Unit
Helios Klinik Müllheim
Heliosweg 1
79379 Müllheim
Meine Fachbereiche

Geriatrie

Neurologie

Stroke Unit - Schlaganfallzentrum

Leitende Oberärztin
2002-2010Medizinstudium an der Albert-Ludwigs-Universität Freiburg
2008Approbation
2010Promotion
2010-2017Assistenzärztin an der Neurologischen Universitätsklinik Freiburg
2017-2018Assistenzärztin an der Psychiatrischen Universitätsklinik Freiburg (im Rahmen der Facharztausbildung Neurologie)
2018Fachärztin für Neurologie
2023Zusatzbezeichnung: Neurologische Intensivmedizin

 

BEI HELIOS

Seit 2022Oberärztin für Neurologie und Geriatrie an der Helios Klinik Müllheim

 

2011GCP (good clinical practice)

 

Schwerpunkte klinischer Arbeit: 

Neurologische Intensivmedizin, insbesondere Schlaganfall-Diagnostik und Therapie
Neuroimmunologische Erkrankungen: Multiple Sklerose, demyelinisierende Erkrankungen des ZNS (insbesondere NMO-SD)
Betreuung klinischer Studien als Co-Investigator: UMBRELLA-Studie (Extensionsstudie/ Langzeitbeobachtung von MS-Patient mit Fingolimod-Behandlung); SPACE 2-Studie (Vergleich von medikamentöser Behandlung mit Carotisendarteriektomie bei Patienten mit asymptomatischer Carotisstenose)

Schwerpunkte wissenschaftlicher Arbeit:

Defizite der räumlich-visuellen Aufmerksamkeit bei Schlaganfall-Patienten in der akuten und chronischen Phase.

Zusatz Qualifikationen

2017Elektroenzephalographie (EEG), DGKN-Zertifikat
2017Spezieller neurologischer Ultraschall, DEGUM-Zertifikat
2018Elektromyographie (EMG), DGKN-Zertifikat
2019Evozierte Potentiale (EP), DGKN-Zertifikat

Mitgliedschaften

Mitglied der Deutsche Gesellschaft für klinische Neurophysiologie (DGKN)
Mitglied der Deutsche Gesellschaft für Neurologie (DGN)
Mitglied im Marburger Bund
1.

Long-term outcome of difficult-to-treat epilepsy in childhood. Beume LA, Steinhoff BJ. Neuropediatrics. 2010 Jun;41(3):135-9. doi: 10.1055/s-0030-1263155. Epub 2010 Sep 21.

PMID: 20859833
2.Coincidence of ischemic stroke and recurrent brain haemorrhage in a patient with Klippel-Trenaunay Syndrome. Beume LA, Fuhrmann SC, Reinhard M, Harloff A. J Clin Neurosci. 2013 Oct;20(10):1454-5. doi: 10.1016/j.jocn.2012.10.039. Epub 2013 Jul 3.PMID: 23830597
3.Massive exacerbation of multiple sclerosis after withdrawal and early restart of treatment with natalizumab. Beume LA, Dersch R, Fuhrer H, Stich O, Rauer S, Niesen WD. J Clin Neurosci. 2015 Feb;22(2):400-1. doi: 10.1016/j.jocn.2014.05.028. Epub 2014 Aug 21. PMID: 25150761PMID: 25150761
4.Processing of bilateral versus unilateral conditions: evidence for the functional contribution of the ventral attention network. Beume LA, Kaller CP, Hoeren M, Klöppel S, Kuemmerer D, Glauche V, Köstering L, Mader I, Rijntjes M, Weiller C, Umarova R. Cortex. 2015 May;66:91-102. doi: 10.1016/j.cortex.2015.02.018. Epub 2015 MarPMID: 25824980
5. Olfactory hallucinations as primary symptom for ischemia in the right posterior insula.
Beume LA, Klingler A, Reinhard M, Niesen WD. J Neurol Sci. 2015 Jul 15;354(1-2):138-9. doi: 10.1016/j.jns.2015.05.014. Epub 2015 May 21. 
PMID: 26025749 No abstract available.
6.  Visual neglect after left-hemispheric lesions: a voxel-based lesion-symptom mapping study in 121 acute stroke patients. Beume LA, Martin M, Kaller CP, Klöppel S, Schmidt CS, Urbach H, Egger K, Rijntjes M, Weiller C, Umarova RM. Exp Brain Res. 2017 Jan;235(1):83-95. doi: 10.1007/s00221-016-4771-9. Epub 2016 Sep 16.PMID: 27637595
7. Large Vessel Occlusion in Acute Stroke. Beume LA, Hieber M, Kaller CP, Nitschke K, Bardutzky J, Urbach H, Weiller C, Rijntjes M. Stroke. 2018 Oct;49(10):2323-2329. doi: 10.1161/STROKEAHA.118.022253.PMID: 30355088
8. Primary intraspinal non-Hodgkin's lymphoma: Case report and review of literature. Beume LA, Wolf K, Urbach H, Klingler JH, Staszewski O, Marks R, Weiller C, Rauer S, Hosp JA. J Clin Neurosci. 2019 Mar;61:262-264. doi: 10.1016/j.jocn.2018.11.046. Epub 2018 Nov 22.PMID: 30472338 Review.
9.Dissociation of visual extinction and neglect in the left hemisphere. Beume LA, Rijntjes M, Dressing A, Kaller CP, Hieber M, Martin M, Kirsch S, Kümmerer D, Urbach H, Umarova RM, Weiller C. Cortex. 2020 Aug;129:211-222. doi: 10.1016/j.cortex.2020.04.010. Epub 2020 Apr 28.PMID: 32505793
10.Full remission in a patient with catheter-associated ventriculitis due to Acinetobacter baumannii treated with intrathecal and intravenous colistin besides coinfections with other multidrug-resistant bacteria. Dersch R, Robinson E, Beume L, Rauer S, Niesen WD. Neurol Sci. 2015 Apr;36(4):633-4. doi: 10.1007/s10072-014-2031-y. Epub 2014 Dec 11.
PMID: 25501805 Review.
11.  Distinct Contributions of Dorsal and Ventral Streams to Imitation of Tool-Use and Communicative Gestures. Dressing A, Nitschke K, Kümmerer D, Bormann T, Beume L, Schmidt CSM, Ludwig VM, Mader I, Willmes K, Rijntjes M, Kaller CP, Weiller C, Martin M. Cereb Cortex. 2018 Feb 1;28(2):474-492. doi: 10.1093/cercor/bhw383.PMID: 27909000
12.Neural correlates of acute apraxia: Evidence from lesion data and functional MRI in stroke patients. Dressing A, Kaller CP, Nitschke K, Beume LA, Kuemmerer D, Schmidt CSM, Bormann T, Umarova RM, Egger K, Rijntjes M, Weiller C, Martin M. Cortex. 2019 Nov;120:1-21. doi: 10.1016/j.cortex.2019.05.005. Epub 2019 May 18.PMID: 31220613
13.The correlation between apraxia and neglect in the right hemisphere: A voxel-based lesion-symptom mapping study in 138 acute stroke patients. Dressing A, Martin M, Beume LA, Kuemmerer D, Urbach H, Kaller CP, Weiller C, Rijntjes M. Cortex. 2020 Nov;132:166-179. doi: 10.1016/j.cortex.2020.07.017. Epub 2020 Sep 2.PMID: 32987240
14.Anatomical correlates of recovery in apraxia: A longitudinal lesion-mapping study in stroke patients. Dressing A, Kaller CP, Martin M, Nitschke K, Kuemmerer D, Beume LA, Schmidt CSM, Musso M, Urbach H, Rijntjes M, Weiller C. Cortex. 2021 Sep;142:104-121. doi: 10.1016/j.cortex.2021.06.001. Epub 2021 Jun 22.PMID: 34265734
15.Tractography of Association Fibers Associated with Language Processing. Egger K, Yang S, Reisert M, Kaller C, Mader I, Beume L, Weiller C, Urbach H. Clin Neuroradiol. 2015 Oct;25 Suppl 2:231-6. doi: 10.1007/s00062-015-0447-2. Epub 2015 Aug 18.PMID: 26280382
16.Long-term outcome changes after mechanical thrombectomy for anterior circulation acute ischemic stroke. Fuhrer H, Forner L, Pruellage P, Weber S, Beume LA, Schacht H, Egger K, Bardutzky J, Weiller C, Urbach H, Niesen WD, Meckel S. J Neurol. 2020 Apr;267(4):1026-1034. doi: 10.1007/s00415-019-09670-w. Epub 2019 Dec 13.PMID: 31834520
17.Neural bases of imitation and pantomime in acute stroke patients: distinct streams for praxis. Hoeren M, Kümmerer D, Bormann T, Beume L, Ludwig VM, Vry MS, Mader I, Rijntjes M, Kaller CP, Weiller C. Brain. 2014 Oct;137(Pt 10):2796-810. doi: 10.1093/brain/awu203. Epub 2014 Jul 24.PMID: 25062694
18. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume LA, Hümmert MW, Trebst C, Ringelstein M, Aktas O, Winkelmann A, Buttmann M, Schwarz A, Zimmermann H, Brandt AU, Franciotta D, Capobianco M, Kuchling J, Haas J, Korporal-Kuhnke M, Lillevang ST, Fechner K, Schanda K, Paul F, Wildemann B, Reindl M; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). J Neuroinflammation. 2016 Sep 26;13(1):279. doi: 10.1186/s12974-016-0717-1.PMID: 27788675 Free PMC article.
19.MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume LA, Hümmert MW, Ringelstein M, Trebst C, Winkelmann A, Schwarz A, Buttmann M, Zimmermann H, Kuchling J, Franciotta D, Capobianco M, Siebert E, Lukas C, Korporal-Kuhnke M, Haas J, Fechner K, Brandt AU, Schanda K, Aktas O, Paul F, Reindl M, Wildemann B; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). J Neuroinflammation. 2016 Sep 27;13(1):280. doi: 10.1186/s12974-016-0718-0.PMID: 27793206 Free PMC article.
20. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome. Jarius S, Kleiter I, Ruprecht K, Asgari N, Pitarokoili K, Borisow N, Hümmert MW, Trebst C, Pache F, Winkelmann A, Beume LA, Ringelstein M, Stich O, Aktas O, Korporal-Kuhnke M, Schwarz A, Lukas C, Haas J, Fechner K, Buttmann M, Bellmann-Strobl J, Zimmermann H, Brandt AU, Franciotta D, Schanda K, Paul F, Reindl M, Wildemann B; in cooperation with the Neuromyelitis Optica Study Group (NEMOS). J Neuroinflammation. 2016 Nov 1;13(1):281. doi: 10.1186/s12974-016-0719-z.PMID: 27802825 Free PMC article.
21.Automated Infarct Core Volumetry Within the Hypoperfused Tissue: Technical Implementation and Evaluation. Kellner E, Reisert M, Kiselev VG, Maurer CJ, Beume LA, Urbach H, Egger K. J Comput Assist Tomogr. 2017 Jul/Aug;41(4):515-520. doi: 10.1097/RCT.0000000000000570.PMID: 27997443
22. Assessment of planning performance in clinical samples: Reliability and validity of the Tower of London task (TOL-F). Köstering L, Schmidt CS, Egger K, Amtage F, Peter J, Klöppel S, Beume LA, Hoeren M, Weiller C, Kaller CP. Neuropsychologia. 2015 Aug;75:646-55. doi: 10.1016/j.neuropsychologia.2015.07.017. Epub 2015 Jul 18.PMID: 26197091
23.Neural correlates of visuospatial bias in patients with left hemisphere stroke: a causal functional contribution analysis based on game theory. Malherbe C, Umarova RM, Zavaglia M, Kaller CP, Beume L, Thomalla G, Weiller C, Hilgetag CC. Neuropsychologia. 2018 Jul 1;115:142-153. doi: 10.1016/j.neuropsychologia.2017.10.013. Epub 2017 Oct 12.PMID: 29031739
24.Differential Roles of Ventral and Dorsal Streams for Conceptual and Production-Related Components of Tool Use in Acute Stroke Patients. Martin M, Beume L, Kümmerer D, Schmidt CS, Bormann T, Dressing A, Ludwig VM, Umarova RM, Mader I, Rijntjes M, Kaller CP, Weiller C. Cereb Cortex. 2016 Sep;26(9):3754-71. doi: 10.1093/cercor/bhv179. Epub 2015 Aug 12.PMID: 26271112
25. Brain activity underlying tool-related and imitative skills after major left hemisphere stroke. Martin M, Nitschke K, Beume L, Dressing A, Bühler LE, Ludwig VM, Mader I, Rijntjes M, Kaller CP, Weiller C. Brain. 2016 May;139(Pt 5):1497-516. doi: 10.1093/brain/aww035. Epub 2016 Mar 8.PMID: 26956421
26.Componential Network for the Recognition of Tool-Associated Actions: Evidence from Voxel-based Lesion-Symptom Mapping in Acute Stroke Patients. Martin M, Dressing A, Bormann T, Schmidt CSM, Kümmerer D, Beume L, Saur D, Mader I, Rijntjes M, Kaller CP, Weiller C. Cereb Cortex. 2017 Aug 1;27(8):4139-4152. doi: 10.1093/cercor/bhw226.PMID: 27497285
27.Are semantic and phonological fluency based on the same or distinct sets of cognitive processes? Insights from factor analyses in healthy adults and stroke patients. Schmidt CSM, Schumacher LV, Römer P, Leonhart R, Beume L, Martin M, Dressing A, Weiller C, Kaller CP. Neuropsychologia. 2017 May;99:148-155. doi: 10.1016/j.neuropsychologia.2017.02.019. Epub 2017 Feb 28.
 
PMID: 28257876
28.Identifying large vessel occlusion at first glance in telemedicine. Schröter N, Weiller A, Rijntjes M, Harloff A, Urbach H, Kukolja J, Bardutzky J, Weiller C, Beume LA. J Neurol. 2023 May 18. doi: 10.1007/s00415-023-11775-2. Online ahead of print.
 
PMID: 37202605
29.Attention-network specific alterations of structural connectivity in the undamaged white matter in acute neglect. Umarova RM, Reisert M, Beier TU, Kiselev VG, Klöppel S, Kaller CP, Glauche V, Mader I, Beume L, Hennig J, Weiller C. Hum Brain Mapp. 2014 Sep;35(9):4678-92. doi: 10.1002/hbm.22503. Epub 2014 Mar 25.PMID: 24668692 Free PMC article.
30. Predictors and signatures of recovery from neglect in acute stroke. Umarova RM, Nitschke K, Kaller CP, Klöppel S, Beume L, Mader I, Martin M, Hennig J, Weiller C. Ann Neurol. 2016 Apr;79(4):673-86. doi: 10.1002/ana.24614. Epub 2016 Mar 15.PMID: 26873402
 
31.Distinct white matter alterations following severe stroke: Longitudinal DTI study in neglect. Umarova RM, Beume L, Reisert M, Kaller CP, Klöppel S, Mader I, Glauche V, Kiselev VG, Catani M, Weiller C. Neurology. 2017 Apr 18;88(16):1546-1555. doi: 10.1212/WNL.0000000000003843. Epub 2017 Mar 22.PMID: 28330962
 
32. Activation of disease during therapy with alemtuzumab in 3 patients with multiple sclerosis. Wehrum T, Beume LA, Stich O, Mader I, Mäurer M, Czaplinski A, Weiller C, Rauer S. Neurology. 2018 Feb 13;90(7):e601-e605. doi: 10.1212/WNL.0000000000004950. Epub 2018 Jan 19.PMID: 29352101
33.The Rydel Seiffer tuning fork - Age and gender matter. Wolf K, Beume LA, Hohenhaus M, Harloff A. Clin Neurol Neurosurg. 2022 Oct;221:107385. doi: 10.1016/j.clineuro.2022.107385. Epub 2022 Jul 23.
 
PMID: 35926295
Helios Klinik Müllheim
Heliosweg 1
79379 Müllheim
Kontakt
Fax: (07631) 88-22 29